Xefo 8 Mg Tab
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Product Description:

Lornoxicam 4 mg film-coated tablets*

What Lornoxicam is used for :

Lornoxicam is a non-steroidal anti-inflammatory drug (NSAID) and antirheumatic drug of the oxicam class.

It is intended in adults for:

• short term symptomatic treatment of acute mild to moderate pain in adults
• symptomatic treatment of pain and inflammation in osteoarthritis in adults
• symptomatic treatment of pain and inflammation in rheumatoid arthritis in adults

Do not take Lornoxicam :

• if you are allergic to Lornoxicam or any of the other ingredients of this medicine;
• if you are hypersensitive to other NSAIDs including acetylsalicylic acid (for instance, aspirin);
• if you suffer from thrombocytopenia (low blood platelet count which increases risk of bleeding or bruising);
• if you suffer from severe heart failure;
• if you suffer from gastrointestinal bleeding, rupture and bleeding of a blood vessel in the
• brain, or other bleeding disorders;
• if you have a history of gastrointestinal bleeding or perforation, related to previous therapy
• with NSAIDs;
• if you suffer from an active peptic ulcer or have a history of recurrent peptic ulcer;
• if you suffer from severe liver impairment;
• if you suffer from severe kidney impairment;
• if you are in the last three months of your pregnancy.

Warnings and precautions :

Talk to your doctor or pharmacist before taking Lornoxicam if you:

• have impaired kidney function;
• have a history of high blood pressure and/or heart failure;
• suffer from ulcerative colitis or Crohn’s disease;
• have a history of bleeding tendency;
• have a history of asthma;
• suffer from SLE (lupus erythematosus, a rare immunological disease).

Possible side effects :

These include a small increase in the risk of heart attack or stroke, unusual abdominal symptoms such as abdominal bleeding, skin reactions such as skin rash, damage to the internal lining of the nostrils, mouth, eyelids, ears, genitals or anus, or other signs of hypersensitivity.

Other medicines and Lornoxicam :

• Tell your doctor or pharmacist if you are taking:
• NSAIDs such as acetylsalicylic acid (for instance, aspirin), ibuprofen and COX-2 inhibitors.
• Cimetidine - used in the treatment of heartburn and peptic ulcers;
• Anticoagulants, such as warfarin, heparin or phenprocoumon - used to prevent the
• formation of blood clots;
• Corticosteroids;
• Methotrexate - used in treatment of cancer and immunological diseases;
• Lithium;
• Immunosuppressive agents, such as cyclosporine or tacrolimus;
• Heart medicines, such as digoxin, ACE-inhibitors, beta-adrenergic blockers;
• Diuretics;
• Quinolone antibiotics (e.g. levofloxacin, ofloxacin);
• Anti-platelet agents (e.g. clopidogrel) - medicines used to prevent heart attacks and strokes;
• SSRI (Selective Serotonin Reuptake Inhibitors) – used in the treatment of depression;
• Sulphonylureas, for instance glibeniclamide - used in the management of diabetes;
• Inducers and inhibitors of CYP2C9-isoenzymes (such as the antibiotic rifampicin or the
• antifungal medicine fluconazole), as they might have an effect on the way in which your
• body breaks down {Invented name};
• Angiotensin II receptor blocker - used to treat high blood pressure, kidney damage due to
• diabetes and congestive heart failure;
• Pemetrexed - used to treat some forms of lung cancer.

How to take Lornoxicam :

The usual dose for adults is 8 to 16 mg, divided in two or three doses per day.

Do not take more than 16 mg a day.

• The dose for patients with arthritis is 12 mg, divided in two or three doses per day.
• Do not take more than 16 mg a day.
• If you have a liver or kidney impairment, do not take more than 12 mg (taken twice or three times a day)
• Lornoxicam tablets must be swallowed with sufficient amounts of liquid.
• Do not take Lornoxicam with a meal, as food can re duce the effectiveness of Lornoxicam.
• Lornoxicam is not recommended for children and adolescents below 18 years old, due to lack of data.

How to store Lornoxicam :

• Keep this medicine out of the sight and reach of children.
• Do not store above 30 degrees Celsius
• Do not use this medicine after the expiry date which is stated on the carton after EXP.
• The expiry date refers to the last day of that month.
• Do not throw away any medicines via wastewater or household waste.
• Ask your pharmacist how to throw away medicines you no longer use. These measures will help protect the environment.

Dosage form and route of administration of Lornoxicam 4 mg film-coated tablets should be prescribed according to therapeutic indication and disease severity of each individual patient.